They lost 1-0 to Red Bull Salzburg on Wednesday. Caoimhin Kelleher, Alisson, Diogo Jota and Alex Oxlade-Chamberlain are out injured. Kostas Tsimikas is doubtful.
Key forward Sadio Mane joined Bayern Munich, but Liverpool strengthened their attack with natural striker Darwin Nuñez.
Liverpool lost 1-0 to Salzburg in their last friendly duel. Coach Klopp opted for a largely second string line-up before bringing on many of his starters in the second half.
Starting goalkeeper Alisson didn't play in the last three friendlies due to injury. He won't be available.
Backup keeper Kelleher is out injured. Third-choice keeper Adrian will fill in. He conceded one goal in the last three games.
Backup midfielder Chamberlain is out injured.
Sometimes starting forward Jota hasn't featured in any preseason friendly due to injury setback. Won't be available.
Backup left-back Tsimikas is an injury doubt.
Liverpool have conceded two or more goals in all their last four games against Man City.
The game will take place at Leicester City's King Power Stadium.
Liverpool will have had less time to rest and prepare for the game than their opponents, since they were last in action on Wednesday, while Man City's last game was on Sunday.