Jon Taylor doubtful; Madger Gomes, Rayhaan Tulloch and Tyreece John-Jules out; Josef Bursik recalled from loan.
Manager Darren Moore has missed the last two games due to self-isolating after coming in contact with someone with Covid-19.
Andy Butler has been in caretaker charge for the last two cup matches.
Louis Jones, Liam Ravenhill and Jason Lokilo and Butler himself started in the 2-1 EFL Trophy defeat to a Wolves B-team.
Taylor Richards made a welcome return to the bench after recovering from injury.
Darren Moore will return to the dugout for the visit from the Black Cats.
He has been dealt a blow with Josef Bursik recalled from his loan by parent club Stoke City.
Joe Lumley will deputise after signing on a 7-day emergency loan from Queens Park Rangers.
Danny Amos and Matt Smith are back in contention after returning from international duty.
Jon Taylor (muscle strain) faces a late fitness test.
Madger Gomes (muscle strain), Tyreece John-Jules (thigh) and Loanee Rayhaan Tulloch (hamstring) are all out.
Doncaster Rovers only ever win over the Black Cats came in an F.A. Cup third round tie in January 1954. They won 2-0 at Roker Park.